Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation (Molecular Cell)

Normal learning and memory require dynamic control of synaptic connections. Arc plays a critical role in modifying synaptic strengths. Zhang et al. reveal that Arc`s function is controlled by a novel regulatory mechanism that exploits its evolutionary origin as a retrotransposon GAG domain together with CaMKII that records activity history.