Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming (Cell Stem Cell)

Zhou et al. performed single-cell RNA sequencing to unravel molecular features of human cardiac reprogramming. They identified a `decision` point where cells either reprogram or regress to initial fate. Further, progression of reprogramming was quantitatively assessed by their developed `cell fate index,` which could be used for studying other biological processes.