TNF-? Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration (Cell Stem Cell)

Passegué and colleagues reveal a complex role for TNF-? in hematopoietic regeneration. Inflammation-induced TNF-? eliminates myeloid progenitors but prevents HSC necroptosis and initiates emergency myelopoiesis through NF-?B-dependent mechanisms, hence promoting HSC survival and hematopoietic regeneration. Persistent TNF-?-driven hematopoietic regeneration underlies chronic inflammation and can contribute to aging and malignant hematopoiesis.