ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection (Cell Host & Microbe)

Degradation of APOBEC3 proteins by HIV Vif hijacking Cullin RING E3 ligase 5 is essential for HIV proliferation. Hüttenhain et al. discovered the host factor ARIH2, which works with CUL5Vif/CBFß via a tag-team mechanism to target APOBEC3 proteins for ubiquitination and is essential for HIV proliferation in primary CD4+ T cells.