A Genetically Tractable, Natural Mouse Model of Cryptosporidiosis Offers Insights into Host Protective Immunity (Cell Host & Microbe)

Cryptosporidiosis is an important diarrheal disease that lacks effective treatment and vaccination. Sateriale et al. isolate Cryptosporidium tyzzeri from naturally infected wild mice and derive a model of infection in immunocompetent mice in which both parasite and host are genetically tractable. The mechanisms of protective immunity are now open to analysis.