Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility (Molecular Cell)

Stavreva et al. reveal a delay between glucocorticoid receptor (GR) binding and RNA synthesis and link GR mobility modulations in time- and treatment-dependent manner to the size and frequency of transcriptional bursts based on single molecule experiments. By reconstructing GR signaling dynamics on timescales ranging from days to milliseconds, they relate single-cell and single-molecule phenomena to glucocorticoid physiology.