Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-?-acetylation of Pgc1? (Molecular Cell)

Lee et al. reveal that Naa10p-mediated N-terminal acetylation of Pgc1? inhibits beige thermogenesis and promotes diet-induced obesity (DIO) in mice. Together with the fact that NAA10 expression positively correlates with human obesity, their results suggest that inhibiting the enzymatic activity of Naa10p in adipose tissues may suppress DIO.