Restitution and Stability of Human Ventricular Action Potential at High And Variable Pacing Rate (Biophysical Journal)

Despite the key role of beat-to-beat action potential (AP) variability in the onset of ventricular arrhythmias at high pacing rate, the knowledge of the involved dynamics and of effective prognostic parameters is largely incomplete. Electrical restitution (ER), the way AP duration (APD) senses changes in preceding cycle length (CL), has been used to monitor transition to arrhythmias. The use of standard ER (sER) though, is controversial, not always suitable for in-vivo, and only rarely for clinical applications.