HIV Rebound Is Predominantly Fueled by Genetically Identical Viral Expansions from Diverse Reservoirs (Cell Host & Microbe)

De Scheerder et al. conduct an in-depth investigation into the origins of HIV rebound. They show that viral rebound originates from multiple compartments and cell proliferation is a driver of viral persistence. Future HIV cure strategies will need to overcome the challenges associated with heterogeneous viral rebound.