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RSS FeedsNeuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain (Current Biology)

 
 

21 october 2019 17:03:34

 
Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain (Current Biology)
 


Wheatley et al. identify O-GlcNAcylation as a key posttranslational modification promoting cognitive rejuvenation. Mimicking age-related decreased neuronal OGT and O-GlcNAc levels in the young hippocampus impaired cognition, while restoring neuronal OGT and O-GlcNAc in the aged hippocampus rejuvenated cognition.


 
178 viewsCategory: Biology
 
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