Distinct RhoGEFs Activate Apical and Junctional Contractility under Control of G Proteins during Epithelial Morphogenesis (Current Biology)

Garcia De Las Bayonas et al. investigate the spatial control of Rho1 signaling that drives contractility during epithelial morphogenesis. They identify two RhoGEFs, which independently activate Rho1 at the medio-apical and junctional compartments in intercalating cells. This process requires upstream control by distinct heterotrimeric G proteins.