Profilin-Mediated Actin Allocation Regulates the Growth of Epithelial Microvilli (Current Biology)

Faust et al. show that the rate of brush border assembly is limited by G-actin availability and that profilin-1 directs unallocated G-actin into growing microvilli during enterocyte differentiation. These findings offer a framework for understanding how epithelial cells cope with the demands of building elaborate apical specializations.