Iterative and Complex Asymmetric Divisions Control Cell Volume Differences in Ciona Notochord Tapering (Current Biology)

Winkley et al. map unequal cleavage throughout the developing notochord in the simple chordate Ciona and find that subtle yet iterative asymmetric divisions play a key role in controlling this organ`s tapered shape. A detailed 3D analysis of spindle positioning points toward multiple underlying mechanisms, including a role for mother cell shape.