Investigation of Proteomic and Phosphoproteomic Responses to Signaling Network Perturbations Reveals Functional Pathway Organizations in Yeast (Cell Reports)

Li et al. measure (phospho)proteomic responses to perturbations of phosphorylation signaling networks in 110 yeast deletion strains. The results emphasize that broad interpretation of phosphorylation data requires protein normalization. Kinase and phosphatase relationships are characterized at both proteome and phosphoproteome levels. Phosphorylation signaling pathway organizations are illuminated by network analyses.