Cell-Cycle Asynchrony Generates DNA Damage at Mitotic Entry in Polyploid Cells (Current Biology)

Nano et al. show that multinucleated polyploid cells can proceed through the cell cycle in an asynchronous manner. Delayed nuclei that are not yet competent to enter mitosis undergo DNA damage when exposed to the mitotic environment of neighboring nuclei. DNA damage can be attenuated by forcing cell-cycle synchronization.