Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast (Molecular Cell)

The ends of DNA breaks are processed to generate single-stranded DNA (ssDNA) in preparation for break repair. Excessive ssDNA may lead to genome instability. Yan et al. find that the DNA repair protein Rad52 restricts the length of ssDNA by limiting access and translocation of RecQ helicases on DNA.