Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies (Cell Host & Microbe)

Antibodies to influenza neuraminidase can provide host protection against influenza virus. Zhu et al. report crystal and cryo-EM structures of N9 neuraminidases from human-infecting H7N9 viruses in complex with five human anti-N9 antibodies, thereby systematically defining neuraminidase antibody epitopes, including the active site.