Acid Derivatives of Pyrazolo[1,5-a]pyrimidine as Aldose Reductase Differential Inhibitors (Cell Chemical Biology)

In this work, Balestri and co-authors provide the evidence that pyrazolopyrimidine derivatives are able to inhibit differently the catalytic activity of aldose reductase, depending on the presence of specific substrates. This finding opens up intriguing opportunities to target long-term diabetic complications while preserving the detoxifying role of the enzyme.