Long-Term Consolidation of Ensemble Neural Plasticity Patterns in Hippocampal Area CA1 (Cell Reports)

Attardo et al. use a fluorescent reporter of neural plasticity to image ensemble plasticity patterns in hippocampal neurons of live mice. These patterns turn over but progressively stabilize across repeated explorations of an enriched environment. In aged mice, plasticity patterns do not stabilize and are less specific to individual environments.