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RSS FeedsTwo Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells (Current Biology)

 
 

15 november 2018 19:00:23

 
Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells (Current Biology)
 


Rata et al. combine quantitative assays with mathematical modeling to show that hysteresis of the mitotic switch emerges from mutual effects of Cdk1 and its counteracting phosphatase, PP2A:B55, on each other`s auto-activation loops. Their work also reveals an intermediate but hidden steady state between interphase and M phase.


 
93 viewsCategory: Biology
 
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