Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-?B Signaling Adaptation (Cell Reports)

de Oliveira Mann et al. define a mechanism that allows emergence of a signaling response in an innate immune pathway. Modular motifs in the STING CTT control the strength and specificity of downstream responses, and evolutionary acquisition of new signaling elements is facilitated by the linear arrangement of the CTT.