Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma (Cell Reports)

Saito et al. were successful in establishing and long-term in vitro culturing of organoids derived from patients with intrahepatic cholangiocarcinoma, gallbladder cancer, and neuroendocrine carcinoma of the ampulla of Vater. Patient-derived organoids can be a powerful preclinical model to identify prognostic biomarkers and therapeutic agents for biliary tract carcinoma.