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RSS FeedsRearrangements within the U6 snRNA Core during the Transition between the Two Catalytic Steps of Splicing (Molecular Cell)

 
 

19 june 2019 23:02:33

 
Rearrangements within the U6 snRNA Core during the Transition between the Two Catalytic Steps of Splicing (Molecular Cell)
 




Cryo-EM structures of catalytic spliceosomes depict the snRNA catalytic core in the same, unchanged conformation. Eysmont et al. show that U6-ISL within the catalytic core toggles between catalytic and non-catalytic conformations due to flexibility within the lower ISL segment. Changes of relative stabilities of these conformations affect splicing fidelity.


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158 viewsCategory: Molecular Biology, Cell Biology
 
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