Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties (Cell Reports)

Dendritic spines on excitatory principal cells are critical sites of learning-induced plasticity. Foggetti et al. report that a subset of parvalbumin-positive interneurons in the dentate gyrus carries high densities of clustered dendritic spines, which predispose for plastic changes in gene expression and affect experience-dependent rewiring.