Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice (Cell Reports)

Zhang et al. report that mast cell deficiency or pharmacological inhibition in mice increases subcutaneous adipose tissue (SAT) adipocyte browning and metabolic rate by increasing SAT PDGFR?+ adipocyte precursor proliferation and beige adipocyte differentiation. Mechanistic analysis demonstrates that MC-derived serotonin inhibits SAT browning and systemic energy expenditure.