Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila (Cell Host & Microbe)

Interorgan communication is required for systemic immune activation in response to local infection, with metabolites playing an important role in this crosstalk. With the Drosophila model, Yang et al. reveal that innate immune signaling in the intestine triggers global immune activation using sugar alcohols of the polyol pathway as an intermediate.