Cell Biology
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11 december 2019 04:00:09 |
| Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1 (Cell Reports) |
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Tweet Song et al. demonstrate that Kindlin-2 inhibits Hippo pathway by enhancing the interaction between MOB1 and E3 ligase praja2 and promoting MOB1 degradation. Kindlin-2 depletion activates the Hippo pathway and alleviates renal fibrosis in UUO mouse model. A specific long-lasting siRNA against Kindlin-2 is of therapeutic value for renal fibrosis. |
| 206 viewsCategory: Cell Biology |
 Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death (Cell Reports)Hypomorphic Expression of Pitx3 Disrupts Circadian Clocks and Prevents Metabolic Entrainment of Energy Expenditure (Cell Reports) 
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