Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair (Developmental Cell)

Mutations in chromatin regulator CHD8 are associated with autism and white matter abnormalities. Zhao et al. show that CHD8 functions in oligodendrocyte progenitors to promote oligodendrocyte lineage development, myelination, and post-injury remyelination by establishing an open chromatin landscape for a cascade of chromatin reprogramming events and recruiting KMT2 histone methyltransferase.