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2 february 2019 15:00:10

 
Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15 (Structure)
 


Teyra et al. developed ubiquitin variants (UbVs) that targeted distinct domains of the deubiquitinase USP15 and revealed alternative inhibition and dimerization strategies. Linear UbV dimers exhibited improved potency and specificity of USP15 inhibition. UbVs can be used to study the catalytic mechanism and biological functions of USP15.


 
91 viewsCategory: Biochemistry
 
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