?-Ketoglutarate-Activated NF-?B Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development (Molecular Cell)

Cancer cells often rewire their metabolic pathways for adaption to nutrient deficiency within tumors. Wang et al. demonstrate here that GDH1 interacts with IKK complex and provides a local source of ?-KG, which directly activates IKK? and NF-?B signaling, thereby promoting glucose uptake, tumor cell survival, and brain tumor development.