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RSS FeedsA PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis (Cell Reports)


17 september 2019 17:03:17

A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis (Cell Reports)

Du et al. identify a signaling cascade that regulates the abundance of H2AX, an essential protein in mediating the DNA damage response. The study links the effect of MTAP loss, a common genetic alteration in cancers, to cancer cells` response to DNA damage insults (e.g., genotoxic agents).

52 viewsCategory: Cell Biology
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