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15 october 2019 04:00:16

Acquired Resistance Is Oncogene and Drug Agnostic (Cancer Cell)

Recent approvals of TRK inhibitors have demonstrated the success of a tumor agnostic approach to oncogene-targeted therapy across cancers. Collective data from acquired resistance studies suggest that resistance mechanisms, which include both kinase domain mutations and bypass signaling via RTK-RAS-RAF-MAPK pathways, frequently recur regardless of tumor type, oncogene, and drug.

45 viewsCategory: Cell Biology, Oncology
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