This article is about the profound misuses, misunderstanding, misinterpretations and misapplications of entropy, the Second Law of Thermodynamics and Information Theory. It is the story of the “Greatest Blunder Ever in the History of Science”. It is not about a single blunder admitted by a single person (e.g., Albert Einstein allegedly said in connection with the cosmological constant, that this was his greatest blunder), but rather a blunder of gargantuan proportions whose claws have permeated all branches of science; from thermodynamics, cosmology, biology, psychology, sociology and much more.