Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria (Cell Host & Microbe)

Mechanisms enabling the host to establish to a privileged relationship with commensal bacteria while preserving protective responses against pathogens remain largely unknown. Leech et al. demonstrate an early-life capacity to distinguish between commensal and pathogenic skin bacteria that preferentially facilitates accumulation of commensal-specific Tregs and immune tolerance.