A Highly Efficient CRISPR-Cas9-Based Genome Engineering Platform in Acinetobacter baumannii to Understand the H2O2-Sensing Mechanism of OxyR (Cell Chemical Biology)

This study reports the establishment of a highly efficient CRISPR-Cas9-based genome engineering platform in a major Gram-negative human pathogen A. baumannii. The genome-editing methods developed in this study would facilitate fundamental physiology study and new therapeutic strategy development in A. baumannii and related organisms.