T-bet+ Memory B Cells Link to Local Cross-Reactive IgG upon Human Rhinovirus Infection (Cell Reports)

Eccles et al. demonstrate a key role for T-bet+ B cells in rapid local cross-reactive immunoglobulin G (IgG) responses to rhinovirus, whereas strain-specific B cells that are phenotypically distinct match systemic antibodies found later. This might explain efficient clearance of virus in the acute phase but narrow protection and continued susceptibility after the infection clears.