Vesicle Shrinking and Enlargement Play Opposing Roles in the Release of Exocytotic Contents (Cell Reports)

Shin et al. discover two fusion modes; one involves fused vesicle shrinking that employs a large pore to facilitate content release, and the other involves vesicle enlargement with a small pore that slows down release. Shrinking is energetically preferred over the generally assumed full-collapse fusion, because osmotic pressure squeezes fused vesicles.