Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor (Cell Reports)

Androgen receptor (AR)-RNA complexes have been implicated in cancer, including melanoma. Schmidt et al. demonstrate that AR binds a single strand sequence in the long non-coding RNA (lncRNA) SLNCR. Point mutations or oligonucleotides that abrogate AR binding to SLNCR block melanoma invasion, suggesting that targeting lncRNA-protein complexes holds therapeutic promise.