DNA Methylation and Histone H1 Jointly Repress Transposable Elements and Aberrant Intragenic Transcripts (Molecular Cell)

Cytosine DNA methylation is common within constitutively expressed plant and animal genes, but its function is unknown. By elucidating the interactions between cytosine methylation and linker histone H1, Choi et al. demonstrate that DNA methylation maintains transcriptional homeostasis by suppressing aberrant intragenic transcription.