The Phosphatase PP1 Promotes Mitotic Slippage through Mad3 Dephosphorylation (Current Biology)

When the spindle assembly checkpoint does not get satisfied for a long time, cells can nonetheless escape from the mitotic arrest through mitotic slippage. Ruggiero et al. find that, in budding yeast, mitotic slippage requires the PP1 phosphatase, which destabilizes the mitotic checkpoint complex through dephosphorylation of its subunit Mad3.