Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5 (Cell Reports)

Vanderleyden et al. show that CXCR5-deficient Treg cells can migrate into the B cell follicle. In the absence of CXCR5, fewer Tfr cells participate in the germinal center reaction, but the reduction in Tfr cell number does not affect the magnitude of the germinal center response.