Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival (Cell Reports)

Burrus et al. show that striatal projection neurons require Huntingtin, the gene mutated in Huntington`s disease, for normal synaptic connectivity, regulated gene expression, and neuronal survival with aging. Loss of Huntingtin from striatal neurons recapitulates several features of Huntington`s disease pathology, an important consideration for therapies non-specifically targeting Huntingtin expression.