TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels (Neuron)

Jia et al. used protein purification, functional reconstitution, and liposome recording to demonstrate that TMC1 and TMC2 proteins are pore-forming subunits of mechanosensitive ion channels, supporting TMC1 and TMC2 as hair cell transduction channels.