Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons (Cell)

3D structures reveal how Latrophilin binds across the Teneurin protein and enable modeling of simultaneous FLRT binding. del Toro et al. show that this trimeric complex is important not only during synapse formation but also in earlier stages of development, where it guides the migration of young neurons by providing repulsive signals.