Autophagy of an Amyloid-like Translational Repressor Regulates Meiotic Exit (Developmental Cell)

Wang et al. report that autophagy promotes meiotic termination by degrading Rim4, an amyloid-like translational repressor whose timed clearance in meiosis II regulates protein production from its mRNA targets. In the absence of autophagy, cells fail to exit meiosis and undergo additional rounds of chromosome segregation after meiosis II.