Reply to Alessia Cimadamore, Marina Scarpelli, Liang Cheng, et al`s Letter to the Editor, re: Maria Chiara Sighinolfi, Bernardo Rocco`s Words of Wisdom re: EAU Guidelines: Prostate Cancer 2019. Mottet N, van den Bergh RCN, Briers E, et al. https://uroweb.org/guideline/prostate-Cancer/. Eur Urol 2019, 76:871 (European Urology)

We read with interest the report from Cimadamore et al [1]. The authors describe a `traumatic neuroma` (TN) as a novel pathological finding. TN could be detected incidentally at the prostate surface during surgery; histologically, it is supposed to arise from a truncated nerve at the periprostatic tissue, maybe deriving--as an inflammatory reaction--from local anesthesia during prostate biopsy (PB) [1]. The occurrence seems rare but also under-reported, given the lack of symptoms and oncological drawbacks.