Protected areas are of national importance and have developed into sources of benefits while in other situations have sparked conflicts among stakeholders, including residents from adjacent local communities, and park authorities. In this study, we examined community residents’ attitudes towards the Kgalagadi Transfrontier Park (KTP) in the Kalahari region (SW Botswana). This study assessed factors that influence support for, or opposition to, the KTP. A questionnaire with semi-structured questions was used to gather information from head of households (N = 746) in nine villages in the Kalahari region. Overall, positive attitudes and support for the KTP as a transfrontier park were documented, though tangible benefits were limited. Further based on analyses, literacy, proximity, and employment status were key variables that influenced support. In addition, any increase in residents’ perceived benefits, land ownership, conservation awareness, and local benefits resulted in increased support for KTP. The implications indicated that communities near the KTP (Botswana side) need to be consulted, while further communications between the KTP management and authorities and adjacent villages are required to initiate effective community conservation programs. Additional programs and community outreach initiatives would also enable positive attitudes and support of KTP.