Neurology
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19 february 2020 23:00:04 |
| Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7 (Neuron) |
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Tweet How does Sirtuin-1 achieve neuroprotection? By studying SCA7, an inherited cerebellar degenerative disorder, Stoyas et al. discover that Sirtuin-1 mediates transcriptional activation of calcium regulatory genes in a NAD-dependent fashion, revealing a number of shared therapy targets for cerebellar ataxia. |
| 187 viewsCategory: Neurology |
 Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits (Neuron)Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model (Neuron) 
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