Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission (Neuron)

Nerve terminals in the brain must synthesize ATP on demand to sustain function. Here, Ashrafi, de Juan-Sanz, et al. show that axonal mitochondria use the brain-specific MCU regulator MICU3 to allow efficient Ca2+ uptake in order to accelerate ATP production.