Click Chemistry in Proteomic Investigations (Cell)

In this Primer, Pratt & Parker overview the biological applications of `click chemistry,` a class of small-molecule reactions that can efficiently conjugate substrates to specific biomolecules. Focusing on proteomic investigations, they provide insight into the biological questions where it may be most useful, including studies of post-translational modifications and protein-protein, protein-drug, and protein-metabolite interactions.